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HUMAN C-REACTIVE PROTEIN

X-ray diffraction
3Å resolution
PDB entry 1gnh coloured by chain, front view.
PDB entry 1gnh coloured by chain, side view.
PDB entry 1gnh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C-reactive protein
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Multimeric state: homo pentamer
Accessible surface area: 42181.61 Å2
Buried surface area: 7390.24 Å2
Dissociation area: 3,330.13 Å2
Dissociation energy (ΔGdiss): -5.28 kcal/mol
Dissociation entropy (TΔSdiss): 52.11 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-136120
Assembly 2
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Assembly Name: C-reactive protein
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Multimeric state: homo pentamer
Accessible surface area: 41954.67 Å2
Buried surface area: 7444.54 Å2
Dissociation area: 3,357.87 Å2
Dissociation energy (ΔGdiss): -4.59 kcal/mol
Dissociation entropy (TΔSdiss): 52.12 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-136120

Macromolecules

C-reactive protein
Chains: A, B, C, D, E, F, G, H, I, J
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Pfam: Pentaxin family
InterPro:
CATH: Jelly Rolls
SCOP: Pentraxin (pentaxin)
C-reactive protein in PDB entry 1gnh, assembly 1, front view.
C-reactive protein in PDB entry 1gnh, assembly 1, side view.
C-reactive protein in PDB entry 1gnh, assembly 1, top view.
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