PDBe 1gng

X-ray diffraction
2.6Å resolution

Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide


Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein. 
ATP + [tau protein] = ADP + [tau protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene FRAT1 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 39 amino acids
Theoretical weight: 4.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q92837 (Residues: 188-226; Coverage: 14%)
Gene name: FRAT1
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 378 amino acids
Theoretical weight: 43.13 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P49841 (Residues: 27-393; Coverage: 87%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: R32
Unit cell:
a: 153.05Å b: 153.05Å c: 213.35Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.196 0.262
Expression systems:
  • Not provided
  • Spodoptera frugiperda