PDBe 1glo

X-ray diffraction
2.2Å resolution

Crystal Structure of Cys25Ser mutant of human cathepsin S

Released:
Source organism: Homo sapiens
Primary publication:
Structure of a Cys25-->Ser mutant of human cathepsin S.
Acta Crystallogr. D Biol. Crystallogr. 58 451-5 (2002)
PMID: 11856830

Function and Biology Details

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin S Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 23.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P25774 (Residues: 115-331; Coverage: 69%)
Gene name: CTSS
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P3121
Unit cell:
a: 79.989Å b: 79.989Å c: 61.517Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.193 0.253
Expression system: Spodoptera frugiperda