Function and Biology

Archaeoglobus fulgidus reverse gyrase complexed with ADPNP

Source organism: Archaeoglobus fulgidus DSM 4304
Biochemical function: reverse gyrase activity
Biological process: DNA unwinding involved in DNA replication
Cellular component: cytoplasm

Sequence families

Pfam Protein families (Pfam)
PF01131
Domain description: DNA topoisomerase
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 4 copies of Pfam domain PF01131 (DNA topoisomerase) in Reverse gyrase. Showing 2 copies in chain A [auth B].

PF01751
Domain description: Toprim domain
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of Pfam domain PF01751 (Toprim domain) in Reverse gyrase. Showing 1 copy in chain A [auth B].

PF00270
Domain description: DEAD/DEAH box helicase
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of Pfam domain PF00270 (DEAD/DEAH box helicase) in Reverse gyrase. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR013497
Domain description: DNA topoisomerase, type IA, central
Occurring in:
  1. Reverse gyrase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Reverse gyrase
IPR006171
Domain description: TOPRIM domain
Occurring in:
  1. Reverse gyrase
IPR005736
Domain description: Reverse gyrase
Occurring in:
  1. Reverse gyrase
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. Reverse gyrase
IPR013826
Domain description: DNA topoisomerase, type IA, central region, subdomain 3
Occurring in:
  1. Reverse gyrase
IPR003602
Domain description: DNA topoisomerase, type IA, DNA-binding domain
Occurring in:
  1. Reverse gyrase
IPR013824
Domain description: DNA topoisomerase, type IA, central region, subdomain 1
Occurring in:
  1. Reverse gyrase
IPR003601
Domain description: DNA topoisomerase, type IA, domain 2
Occurring in:
  1. Reverse gyrase
IPR034142
Domain description: Reverse gyrase, TOPRIM domain
Occurring in:
  1. Reverse gyrase
IPR023405
Domain description: DNA topoisomerase, type IA, core domain
Occurring in:
  1. Reverse gyrase
IPR011545
Domain description: DEAD/DEAH box helicase domain
Occurring in:
  1. Reverse gyrase

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 4 copies of CATH domain 3.40.50.300 (Rossmann fold) in Reverse gyrase. Showing 2 copies in chain A [auth B].
2.60.510.20
Class: Mainly Beta
Architecture: Sandwich
Topology: EV matrix protein fold
Homology: EV matrix protein fold
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of CATH domain 2.60.510.20 (EV matrix protein fold) in Reverse gyrase. Showing 1 copy in chain A [auth B].
1.10.460.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Topoisomerase I; domain 2
Homology: Topoisomerase I, domain 2
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of CATH domain 1.10.460.10 (Topoisomerase I; domain 2) in Reverse gyrase. Showing 1 copy in chain A [auth B].
3.40.50.140
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of CATH domain 3.40.50.140 (Rossmann fold) in Reverse gyrase. Showing 1 copy in chain A [auth B].
2.20.20.30
Class: Mainly Beta
Architecture: Single Sheet
Topology: Anthopleurin-A
Homology: reverse gyrase domain
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of CATH domain 2.20.20.30 (Anthopleurin-A) in Reverse gyrase. Showing 1 copy in chain A [auth B].
1.10.290.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Topoisomerase I; domain 4
Homology: Topoisomerase I, domain 4
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of CATH domain 1.10.290.10 (Topoisomerase I; domain 4) in Reverse gyrase. Showing 1 copy in chain A [auth B].
3.30.56.120
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phenylalanyl-tRNA Synthetase; Chain B, domain 1
Homology: Phenylalanyl-tRNA Synthetase; Chain B, domain 1
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of CATH domain 3.30.56.120 (Phenylalanyl-tRNA Synthetase; Chain B, domain 1) in Reverse gyrase. Showing 1 copy in chain A [auth B].
SCOP SCOP annotations
69496
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 4 copies of SCOP domain 69496 (Helicase-like in Reverse gyrase. Showing 2 copies in chain A [auth B].">
56713
Class: Multi-domain proteins (alpha and beta)
Fold: Prokaryotic type I DNA topoisomerase
Superfamily: Prokaryotic type I DNA topoisomerase
Occurring in:
  1. Reverse gyrase
The deposited structure of PDB entry 1gl9 contains 2 copies of SCOP domain 56713 (Prokaryotic type I DNA topoisomerase) in Reverse gyrase. Showing 1 copy in chain A [auth B].