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HUMAN FACTOR XIII WITH CALCIUM BOUND IN THE ION SITE

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: blood coagulation, fibrin clot formation
Cellular component: transferase complex

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EC 2.3.2.13: Protein-glutamine gamma-glutamyltransferase

Reaction catalysed:
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3)
Systematic name:
Protein-L-glutamine:protein-L-lysine gamma-glutamyltransferase
Alternative Name(s):
  • Factor XIIIa
  • Fibrin stabilizing factor
  • Fibrinoligase
  • Glutaminylpeptide gamma-glutamyltransferase
  • Polyamine transglutaminase
  • Protein-glutamine:amine gamma-glutamyltransferase
  • R-glutaminyl-peptide:amine gamma-glutamyl transferase
  • TGase
  • Tissue transglutaminase
  • Transglutaminase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00927
Domain description: Transglutaminase family, C-terminal ig like domain
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 4 copies of Pfam domain PF00927 (Transglutaminase family, C-terminal ig like domain) in Coagulation factor XIII A chain. Showing 2 copies in chain B.

PF01841
Domain description: Transglutaminase-like superfamily
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 2 copies of Pfam domain PF01841 (Transglutaminase-like superfamily) in Coagulation factor XIII A chain. Showing 1 copy in chain B.

PF00868
Domain description: Transglutaminase family
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 2 copies of Pfam domain PF00868 (Transglutaminase family) in Coagulation factor XIII A chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Coagulation factor XIII A chain
IPR008958
Domain description: Transglutaminase, C-terminal
Occurring in:
  1. Coagulation factor XIII A chain
IPR036238
Domain description: Transglutaminase, C-terminal domain superfamily
Occurring in:
  1. Coagulation factor XIII A chain
IPR002931
Domain description: Transglutaminase-like
Occurring in:
  1. Coagulation factor XIII A chain
IPR013808
Domain description: Transglutaminase, active site
Occurring in:
  1. Coagulation factor XIII A chain
IPR036985
Domain description: Transglutaminase-like superfamily
Occurring in:
  1. Coagulation factor XIII A chain
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Coagulation factor XIII A chain
IPR001102
Domain description: Transglutaminase, N-terminal
Occurring in:
  1. Coagulation factor XIII A chain
IPR023608
Domain description: Protein-glutamine gamma-glutamyltransferase, animal
Occurring in:
  1. Coagulation factor XIII A chain
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Coagulation factor XIII A chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 6 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Coagulation factor XIII A chain. Showing 3 copies in chain B.
3.90.260.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Coagulation Factor XIII; Chain A, domain 2
Homology: Transglutaminase-like
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 2 copies of CATH domain 3.90.260.10 (Coagulation Factor XIII; Chain A, domain 2) in Coagulation factor XIII A chain. Showing 1 copy in chain B.
SCOP SCOP annotations
49310
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Transglutaminase, two C-terminal domains
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 4 copies of SCOP domain 49310 (Transglutaminase, two C-terminal domains) in Coagulation factor XIII A chain. Showing 2 copies in chain B.
54044
Class: Alpha and beta proteins (a+b)
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 2 copies of SCOP domain 54044 (Transglutaminase core) in Coagulation factor XIII A chain. Showing 1 copy in chain B.
81289
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Coagulation factor XIII A chain
The deposited structure of PDB entry 1ggu contains 2 copies of SCOP domain 81289 (Transglutaminase N-terminal domain) in Coagulation factor XIII A chain. Showing 1 copy in chain B.

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