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CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT THE SURFACE POSITIONS

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: defense response to Gram-positive bacterium
Cellular component: tertiary granule lumen

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EC 3.2.1.17: Lysozyme

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Systematic name:
Peptidoglycan N-acetylmuramoylhydrolase
Alternative Name(s):
  • 1,4-N-acetylmuramidase
  • Globulin G
  • Globulin G1
  • L-7001
  • Lysozyme g
  • Mucopeptide N-acetylmuramoylhydrolase
  • Mucopeptide glucohydrolase
  • Muramidase
  • N,O-diacetylmuramidase
  • PR1-lysozyme

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00062
Domain description: C-type lysozyme/alpha-lactalbumin family
Occurring in:
  1. Lysozyme C
The deposited structure of PDB entry 1gfr contains 1 copy of Pfam domain PF00062 (C-type lysozyme/alpha-lactalbumin family) in Lysozyme C. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001916
Domain description: Glycoside hydrolase, family 22
Occurring in:
  1. Lysozyme C
IPR000974
Domain description: Glycoside hydrolase, family 22, lysozyme
Occurring in:
  1. Lysozyme C
IPR019799
Domain description: Glycoside hydrolase family 22 domain
Occurring in:
  1. Lysozyme C
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. Lysozyme C

Structure domain

CATH CATH domain
1.10.530.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Lysozyme
Homology: Lysozyme
Occurring in:
  1. Lysozyme C
The deposited structure of PDB entry 1gfr contains 1 copy of CATH domain 1.10.530.10 (Lysozyme) in Lysozyme C. Showing 1 copy in chain A.
SCOP SCOP annotation
53960
Class: Alpha and beta proteins (a+b)
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Occurring in:
  1. Lysozyme C
The deposited structure of PDB entry 1gfr contains 1 copy of SCOP domain 53960 (C-type lysozyme) in Lysozyme C. Showing 1 copy in chain A.

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