PDBe 1gcq

X-ray diffraction
1.68Å resolution

CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene vav Chain: C
Molecule details ›
Chain: C
Length: 70 amino acids
Theoretical weight: 8.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P27870 (Residues: 595-660; Coverage: 8%)
Gene names: Vav, Vav1
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Growth factor receptor-bound protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 61 amino acids
Theoretical weight: 7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 159-217; Coverage: 27%)
Gene names: ASH, GRB2
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2221
Unit cell:
a: 48.05Å b: 126.82Å c: 83.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.201 0.235
Expression system: Escherichia coli