PDBe 1gbr

Solution NMR

ORIENTATION OF PEPTIDE FRAGMENTS FROM SOS PROTEINS BOUND TO THE N-TERMINAL SH3 DOMAIN OF GRB2 DETERMINED BY NMR SPECTROSCOPY

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Son of sevenless homolog 2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.77 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q02384 (Residues: 1300-1314; Coverage: 1%)
Gene name: Sos2
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.45 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q60631 (Residues: 1-61; Coverage: 28%)
  • Best match: Q60631-2 (Residues: 1-59)
Gene name: Grb2
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Not provided
  • Escherichia coli BL21