PDBe 1gbq

Solution NMR

SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, MINIMIZED AVERAGE STRUCTURE

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.45 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q60631 (Residues: 1-61; Coverage: 28%)
Gene name: Grb2
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Son of sevenless homolog 1 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.2 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q62245 (Residues: 1135-1144; Coverage: 1%)
Gene name: Sos1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DG, SA
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided