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1.2 A structure of T3R3 human insulin at 100 K

X-ray diffraction
1.2Å resolution
PDB entry 1g7a coloured by chain, front view.
PDB entry 1g7a coloured by chain, side view.
PDB entry 1g7a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 13382.18 Å2
Buried surface area: 18753.61 Å2
Dissociation area: 99.14 Å2
Dissociation energy (ΔGdiss): 23.69 kcal/mol
Dissociation entropy (TΔSdiss): 1.07 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235
Assembly 2 (preferred)
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 13159.71 Å2
Buried surface area: 19337.06 Å2
Dissociation area: 352.73 Å2
Dissociation energy (ΔGdiss): 13.12 kcal/mol
Dissociation entropy (TΔSdiss): 4.39 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Insulin A chain
Chains: A, C, E, G
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1g7a, assembly 2, front view.
Insulin A chain in PDB entry 1g7a, assembly 2, side view.
Insulin A chain in PDB entry 1g7a, assembly 2, top view.
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Insulin B chain
Chains: B, D, F, H
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1g7a, assembly 2, front view.
Insulin B chain in PDB entry 1g7a, assembly 2, side view.
Insulin B chain in PDB entry 1g7a, assembly 2, top view.
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