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EPID H67N COMPLEXED WITH SUBSTRATE PEPTIDE DSYTC

X-ray diffraction
2.57Å resolution
PDB entry 1g5q coloured by chain, front view.
PDB entry 1g5q coloured by chain, side view.
PDB entry 1g5q coloured by chain, top view.
Source organism: Staphylococcus epidermidis
Assembly composition:
hetero 24-mer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lantibiotic epidermin and Epidermin decarboxylase
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Multimeric state: hetero 24-mer
Accessible surface area: 66148.14 Å2
Buried surface area: 62110.0 Å2
Dissociation area: 7,587.67 Å2
Dissociation energy (ΔGdiss): 92.9 kcal/mol
Dissociation entropy (TΔSdiss): 45.25 kcal/mol
Symmetry number: 12
PDBe Complex ID: PDB-CPX-139925

Macromolecules

Epidermin decarboxylase
Chains: A, D, G, L
Length: 181 amino acids
Theoretical weight: 20.82 KDa
Source organism: Staphylococcus epidermidis
Expression system: Escherichia coli
UniProt:
  • Canonical: P30197 (Residues: 1-181; Coverage: 100%)
Gene name: epiD
Pfam: Flavoprotein
InterPro:
CATH: Flavin prenyltransferase-like
SCOP: Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
Epidermin decarboxylase in PDB entry 1g5q, assembly 1, front view.
Epidermin decarboxylase in PDB entry 1g5q, assembly 1, side view.
Epidermin decarboxylase in PDB entry 1g5q, assembly 1, top view.
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Lantibiotic epidermin
Chains: M, N, O, P
Length: 5 amino acids
Theoretical weight: 588 Da
Source organism: Staphylococcus epidermidis
Expression system: Not provided
UniProt:
  • Canonical: P08136 (Residues: 48-52; Coverage: 10%)
Gene name: epiA
Lantibiotic epidermin in PDB entry 1g5q, assembly 1, front view.
Lantibiotic epidermin in PDB entry 1g5q, assembly 1, side view.
Lantibiotic epidermin in PDB entry 1g5q, assembly 1, top view.
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