PDBe 1g50

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF A WILD TYPE HER ALPHA LBD AT 2.9 ANGSTROM RESOLUTION

Released:
Source organism: Homo sapiens
Primary publication:
Overexpression, purification, and crystal structure of native ER alpha LBD.
Protein Expr. Purif. 22 165-73 (2001)
PMID: 11437591

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 247 amino acids
Theoretical weight: 28.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 304-550; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P3221
Unit cell:
a: 105.5Å b: 105.5Å c: 136.08Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.241 0.31
Expression system: Escherichia coli BL21(DE3)