PDBe 1fu5

Solution NMR

NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Middle T antigen Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 2.06 KDa
Source organism: Mus musculus polyomavirus 1
Expression system: Not provided
UniProt:
  • Canonical: P0DOJ9 (Residues: 312-326; Coverage: 4%)
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.87 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63787 (Residues: 321-431; Coverage: 15%)
Gene name: Pik3r1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Refinement method: The structures were energy minimized with MSI DISCOVER.
Expression systems:
  • Not provided
  • Escherichia coli