PDBe 1fs2

X-ray diffraction
2.9Å resolution

INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
S-phase kinase-associated protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 141 amino acids
Theoretical weight: 16.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63208 (Residues: 1-147; Coverage: 87%)
Gene names: EMC19, OCP2, SKP1, SKP1A, TCEB1L
Structure domains: Potassium Channel Kv1.1; Chain A
S-phase kinase-associated protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 272 amino acids
Theoretical weight: 30.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13309 (Residues: 89-398; Coverage: 64%)
  • Best match: Q13309-4 (Residues: 10-184)
Gene names: FBXL1, SKP2
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 72.67Å b: 87.02Å c: 178.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.246 0.287
Expression system: Escherichia coli