PDBe 1fro

X-ray diffraction
2.2Å resolution

HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR

Released:

Function and Biology Details

Reaction catalysed:
(R)-S-lactoylglutathione = glutathione + methylglyoxal. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactoylglutathione lyase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 183 amino acids
Theoretical weight: 20.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04760 (Residues: 2-184; Coverage: 100%)
Gene name: GLO1
Sequence domains: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Structure domains: 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43
Unit cell:
a: 68Å b: 68Å c: 169.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.234
Expression system: Escherichia coli