Function and Biology

TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: regulation of transcription, DNA-templated
Cellular component: transcription factor complex

Sequence family

CATH InterPro annotations
IPR004827
Domain description: Basic-leucine zipper domain
Occurring in:
  1. Proto-oncogene c-Fos
  2. Transcription factor AP-1
IPR002112
Domain description: Transcription factor Jun
Occurring in:
  1. Transcription factor AP-1
IPR000837
Domain description: AP-1 transcription factor
Occurring in:
  1. Proto-oncogene c-Fos
IPR029816
Domain description: c-Fos/v-Fos
Occurring in:
  1. Proto-oncogene c-Fos
IPR015558
Domain description: Transcription Factor c-Jun/v-Jun
Occurring in:
  1. Transcription factor AP-1

Structure domain

CATH CATH domain
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Proto-oncogene c-Fos
  2. Transcription factor AP-1
1 copy of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Proto-oncogene c-Fos in PDB 1fos.
2 copies of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Transcription factor AP-1 in PDB 1fos.
SCOP SCOP annotation
57960
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Leucine zipper domain
Occurring in:
  1. Proto-oncogene c-Fos
  2. Transcription factor AP-1
1 copy of SCOP domain 57960 (Leucine zipper domain) in Proto-oncogene c-Fos in PDB 1fos.
2 copies of SCOP domain 57960 (Leucine zipper domain) in Transcription factor AP-1 in PDB 1fos.