Structure analysis

TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES

X-ray diffraction
3.05Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 15000 Å2
Buried surface area: 6400 Å2
Dissociation area: 1,200 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -46 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 14800 Å2
Buried surface area: 6600 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): 12 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -48 kcal/mol
Symmetry number: 1

Macromolecules

Chains: E, G
Length: 62 amino acids
Theoretical weight: 7.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01100 (Residues: 139-200; Coverage: 16%)
Gene names: FOS, G0S7
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain

Search similar proteins

Name: DNA (5'-D(*AP*AP*TP*GP*GP*AP*TP*GP*AP*GP*TP*CP*AP*TP*AP*GP*GP*AP*GP*A)-3')
Representative chains: A, C
Length: 20 nucleotides
Theoretical weight: 6.27 KDa

Search similar DNA

Name: DNA (5'-D(*TP*TP*CP*TP*CP*CP*TP*AP*TP*GP*AP*CP*TP*CP*AP*TP*CP*CP*AP*T)-3')
Representative chains: B, D
Length: 20 nucleotides
Theoretical weight: 5.99 KDa

Search similar DNA