PDBe 1ff1

Solution NMR

STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFL

Released:
Primary publication:
Molecular mechanism of NPF recognition by EH domains.
Nat. Struct. Biol. 7 1018-22 (2000)
PMID: 11062555

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PTGSSSTNPFL PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.11 KDa
Source organism: Synthetic construct
Expression system: Not provided
Epidermal growth factor receptor substrate 15 Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42566 (Residues: 121-215; Coverage: 11%)
Gene names: AF1P, EPS15
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Not provided
  • Escherichia coli