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CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.

X-ray diffraction
3Å resolution
PDB entry 1fe2 coloured by chain, front view.
PDB entry 1fe2 coloured by chain, side view.
PDB entry 1fe2 coloured by chain, top view.
Source organism: Ovis aries
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Prostaglandin G/H synthase 1
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Multimeric state: homo dimer
Accessible surface area: 41517.61 Å2
Buried surface area: 16848.43 Å2
Dissociation area: 3,034.28 Å2
Dissociation energy (ΔGdiss): 12.92 kcal/mol
Dissociation entropy (TΔSdiss): 15.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138844

Macromolecules

Prostaglandin G/H synthase 1
Chain: A
Length: 576 amino acids
Theoretical weight: 66.16 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 25-600; Coverage: 100%)
Gene names: COX1, PTGS1
Pfam: Animal haem peroxidase
InterPro:
CATH:
SCOP:
Prostaglandin G/H synthase 1 in PDB entry 1fe2, assembly 1, front view.
Prostaglandin G/H synthase 1 in PDB entry 1fe2, assembly 1, side view.
Prostaglandin G/H synthase 1 in PDB entry 1fe2, assembly 1, top view.
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