PDBe 1fe2

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.

Released:

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chain: A
Molecule details ›
Chain: A
Length: 576 amino acids
Theoretical weight: 66.16 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 25-600; Coverage: 100%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6522
Unit cell:
a: 182.19Å b: 182.19Å c: 103.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.237 0.277