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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE PANAGONIST RETINOID BMS181156

X-ray diffraction
1.38Å resolution
PDB entry 1fcz coloured by chain, front view.
PDB entry 1fcz coloured by chain, side view.
PDB entry 1fcz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Retinoic acid receptor gamma
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Multimeric state: monomeric
Accessible surface area: 11273.89 Å2
Buried surface area: 1545.78 Å2
Dissociation area: 425.29 Å2
Dissociation energy (ΔGdiss): -9.95 kcal/mol
Dissociation entropy (TΔSdiss): 4.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146677

Macromolecules

Retinoic acid receptor gamma
Chain: A
Length: 235 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13631 (Residues: 183-417; Coverage: 52%)
Gene names: NR1B3, RARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Retinoic acid receptor gamma in PDB entry 1fcz, assembly 1, front view.
Retinoic acid receptor gamma in PDB entry 1fcz, assembly 1, side view.
Retinoic acid receptor gamma in PDB entry 1fcz, assembly 1, top view.
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