PDBe 1fav

X-ray diffraction
3Å resolution

THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41; General control protein GCN4 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.27 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P03377 (Residues: 546-595; Coverage: 6%)
  • Canonical: P03069 (Residues: 252-280; Coverage: 10%)
  • nullnull
Gene names: AAS3, ARG9, GCN4, YEL009C, env
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Transmembrane protein gp41 Chain: C
Molecule details ›
Chain: C
Length: 33 amino acids
Theoretical weight: 4.05 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 636-665; Coverage: 4%)
Gene name: env

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: P321
Unit cell:
a: 35.819Å b: 35.819Å c: 164.691Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.24 0.295
Expression systems:
  • Escherichia coli
  • Not provided