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CASPASE-8 SPECIFICITY PROBED AT SUBSITE S4: CRYSTAL STRUCTURE OF THE CASPASE-8-Z-DEVD-CHO

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.61: Caspase-8

Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala)
Systematic name:
-
Alternative Name(s):
  • Apoptotic cysteine protease
  • Apoptotic protease Mch-5
  • CAP4
  • CASP-8
  • FADD-homologous ICE/CED-3-like protease
  • FADD-like ICE
  • FLICE
  • ICE-like apoptotic protease 5
  • MACH
  • MORT1-associated CED-3 homolog
  • Mammalian Ced-3 homolog 5
  • Mch5

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00656
Domain description: Caspase domain
Occurring in:
  1. Caspase-8 subunit p18
  2. Caspase-8 subunit p10
The deposited structure of PDB entry 1f9e contains 6 copies of Pfam domain PF00656 (Caspase domain) in Caspase-8 subunit p18. Showing 1 copy in chain A.
The deposited structure of PDB entry 1f9e contains 6 copies of Pfam domain PF00656 (Caspase domain) in Caspase-8 subunit p10. Showing 1 copy in chain N [auth J].

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-8 subunit p18
  2. Caspase-8 subunit p10
IPR011600
Domain description: Peptidase C14, caspase domain
Occurring in:
  1. Caspase-8 subunit p18
  2. Caspase-8 subunit p10
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-8 subunit p18
  2. Caspase-8 subunit p10
IPR002138
Domain description: Peptidase C14, caspase non-catalytic subunit p10
Occurring in:
  1. Caspase-8 subunit p10
IPR033139
Domain description: Peptidase family C14A, cysteine active site
Occurring in:
  1. Caspase-8 subunit p18
IPR016129
Domain description: Peptidase family C14A, His active site
Occurring in:
  1. Caspase-8 subunit p18
IPR001309
Domain description: Peptidase C14, p20 domain
Occurring in:
  1. Caspase-8 subunit p18

Structure domains

CATH CATH domains
3.30.70.1470
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Caspase-like
Occurring in:
  1. Caspase-8 subunit p10
The deposited structure of PDB entry 1f9e contains 6 copies of CATH domain 3.30.70.1470 (Alpha-Beta Plaits) in Caspase-8 subunit p10. Showing 1 copy in chain B.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-8 subunit p18
The deposited structure of PDB entry 1f9e contains 6 copies of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-8 subunit p18. Showing 1 copy in chain A.
SCOP SCOP annotation
52130
Class: Alpha and beta proteins (a/b)
Fold: Caspase-like
Superfamily: Caspase-like
Occurring in:
  1. Caspase-8 subunit p18
  2. Caspase-8 subunit p10
The deposited structure of PDB entry 1f9e contains 6 copies of SCOP domain 52130 (Caspase catalytic domain) in Caspase-8 subunit p18. Showing 1 copy in chain A.

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