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THE FIRST EGF-LIKE DOMAIN FROM HUMAN BLOOD COAGULATION FVII, NMR, MINIMIZED AVERAGE STRUCTURE

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.4.21.21: Coagulation factor VIIa

Reaction catalysed:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Alternative Name(s):
  • Activated blood coagulation factor VII
  • Blood-coagulation factor VIIa

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00008
Domain description: EGF-like domain
Occurring in:
  1. Factor VII light chain
The deposited structure of PDB entry 1f7m contains 1 copy of Pfam domain PF00008 (EGF-like domain) in Factor VII light chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Factor VII light chain
IPR000152
Domain description: EGF-type aspartate/asparagine hydroxylation site
Occurring in:
  1. Factor VII light chain
IPR018097
Domain description: EGF-like calcium-binding, conserved site
Occurring in:
  1. Factor VII light chain
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Factor VII light chain

Structure domain

CATH CATH domain
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Factor VII light chain
The deposited structure of PDB entry 1f7m contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Factor VII light chain. Showing 1 copy in chain A.
SCOP SCOP annotation
57197
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Factor VII light chain
The deposited structure of PDB entry 1f7m contains 1 copy of SCOP domain 57197 (EGF-type module) in Factor VII light chain. Showing 1 copy in chain A.

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