PDBe 1f5q

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin D homolog Chains: B, D
Molecule details ›
Chains: B, D
Length: 252 amino acids
Theoretical weight: 29.07 KDa
Source organism: Murid gammaherpesvirus 4
Expression system: Escherichia coli
UniProt:
  • Canonical: P89883 (Residues: 1-252; Coverage: 100%)
Gene names: 72, GAMMAHV.ORF72, v-cyclin
Sequence domains: Cyclin, N-terminal domain
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 87.59Å b: 73.45Å c: 107.67Å
α: 90° β: 102.18° γ: 90°
R-values:
R R work R free
0.234 0.234 0.278
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda