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Crystal structure of the complex between the N-terminal domain of TRADD and the TRAF domain of TRAF2

X-ray diffraction
2Å resolution
PDB entry 1f3v coloured by chain, front view.
PDB entry 1f3v coloured by chain, side view.
PDB entry 1f3v coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TNF receptor-associated factor 2 and Tumor necrosis factor receptor type 1-associated DEATH domain protein
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Multimeric state: hetero dimer
Accessible surface area: 15997.52 Å2
Buried surface area: 1485.43 Å2
Dissociation area: 742.72 Å2
Dissociation energy (ΔGdiss): -3.16 kcal/mol
Dissociation entropy (TΔSdiss): 11.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171448

Macromolecules

Tumor necrosis factor receptor type 1-associated DEATH domain protein
Chain: A
Length: 179 amino acids
Theoretical weight: 19.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15628 (Residues: 1-179; Coverage: 57%)
Gene name: TRADD
Pfam: TRADD, N-terminal domain
InterPro:
CATH: TRADD, N-terminal domain
SCOP: TRADD, N-terminal domain
Tumor necrosis factor receptor type 1-associated DEATH domain protein in PDB entry 1f3v, assembly 1, front view.
Tumor necrosis factor receptor type 1-associated DEATH domain protein in PDB entry 1f3v, assembly 1, side view.
Tumor necrosis factor receptor type 1-associated DEATH domain protein in PDB entry 1f3v, assembly 1, top view.
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TNF receptor-associated factor 2
Chain: B
Length: 171 amino acids
Theoretical weight: 19.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12933 (Residues: 331-501; Coverage: 34%)
Gene names: TRAF2, TRAP3
Pfam: TRAF/meprin, MATH domain
InterPro:
CATH: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
SCOP:
TNF receptor-associated factor 2 in PDB entry 1f3v, assembly 1, front view.
TNF receptor-associated factor 2 in PDB entry 1f3v, assembly 1, side view.
TNF receptor-associated factor 2 in PDB entry 1f3v, assembly 1, top view.
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