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DIVALENT METAL COFACTOR BINDING IN THE KINETIC FOLDING TRAJECTORY OF E. COLI RIBONUCLEASE HI

Source organism: Escherichia coli
Biochemical function: metal ion binding
Biological process: DNA replication, removal of RNA primer
Cellular component: cytoplasm

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EC 3.1.26.4: Ribonuclease H

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester.
Systematic name:
-
Alternative Name(s):
  • Calf thymus ribonuclease H
  • Endoribonuclease H
  • Endoribonuclease H (calf thymus)
  • Hybrid nuclease
  • Hybrid ribonuclease
  • Hybridase
  • Hybridase (ribonuclease H)
  • RNA*DNA hybrid ribonucleotidohydrolase
  • RNase H

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00075
Domain description: RNase H
Occurring in:
  1. Ribonuclease HI
The deposited structure of PDB entry 1f21 contains 1 copy of Pfam domain PF00075 (RNase H) in Ribonuclease HI. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022892
Domain description: Ribonuclease HI
Occurring in:
  1. Ribonuclease HI
IPR002156
Domain description: Ribonuclease H domain
Occurring in:
  1. Ribonuclease HI
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Ribonuclease HI
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Ribonuclease HI

Structure domain

CATH CATH domain
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Ribonuclease HI
The deposited structure of PDB entry 1f21 contains 1 copy of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Ribonuclease HI. Showing 1 copy in chain A.
SCOP SCOP annotation
53099
Class: Alpha and beta proteins (a/b)
Fold: Ribonuclease H-like motif
Superfamily: Ribonuclease H-like
Occurring in:
  1. Ribonuclease HI
The deposited structure of PDB entry 1f21 contains 1 copy of SCOP domain 53099 (Ribonuclease H) in Ribonuclease HI. Showing 1 copy in chain A.

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