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L-3-HYDROXYACYL-COA DEHYDROGENASE COMPLEXED WITH 3-HYDROXYBUTYRYL-COA

Source organism: Homo sapiens
Biochemical function: NAD+ binding
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: mitochondrial matrix

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EC 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase

Reaction catalysed:
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
Systematic name:
(S)-3-hydroxyacyl-CoA:NAD(+) oxidoreductase
Alternative Name(s):
  • 1-specific DPN-linked beta-hydroxybutyric dehydrogenase
  • 3-L-hydroxyacyl-CoA dehydrogenase
  • 3-beta-hydroxyacyl coenzyme A dehydrogenase
  • 3-hydroxyacetyl-coenzyme A dehydrogenase
  • 3-hydroxyacyl coenzyme A dehydrogenase
  • 3-hydroxybutyryl-CoA dehydrogenase
  • 3-hydroxyisobutyryl-CoA dehydrogenase
  • 3-keto reductase
  • Beta-hydroxy acid dehydrogenase
  • Beta-hydroxyacyl CoA dehydrogenase
  • Beta-hydroxyacyl dehydrogenase
  • Beta-hydroxyacyl-coenzyme A synthetase
  • Beta-hydroxyacylcoenzyme A dehydrogenase
  • Beta-hydroxybutyrylcoenzyme A dehydrogenase
  • Beta-keto-reductase
  • Beta-ketoacyl-CoA reductase
  • L-3-hydroxyacyl CoA dehydrogenase
  • L-3-hydroxyacyl coenzyme A dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00725
Domain description: 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
The deposited structure of PDB entry 1f12 contains 2 copies of Pfam domain PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.

PF02737
Domain description: 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
The deposited structure of PDB entry 1f12 contains 2 copies of Pfam domain PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013328
Domain description: 6-phosphogluconate dehydrogenase, domain 2
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
IPR006108
Domain description: 3-hydroxyacyl-CoA dehydrogenase, C-terminal
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
IPR008927
Domain description: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
IPR006180
Domain description: 3-hydroxyacyl-CoA dehydrogenase, conserved site
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
IPR006176
Domain description: 3-hydroxyacyl-CoA dehydrogenase, NAD binding
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
IPR022694
Domain description: 3-hydroxyacyl-CoA dehydrogenase
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Structure domains

CATH CATH domains
1.10.1040.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homology: N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
The deposited structure of PDB entry 1f12 contains 2 copies of CATH domain 1.10.1040.10 (N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
The deposited structure of PDB entry 1f12 contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotations
48187
Class: All alpha proteins
Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like
Superfamily: 6-phosphogluconate dehydrogenase C-terminal domain-like
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
The deposited structure of PDB entry 1f12 contains 2 copies of SCOP domain 48187 (HCDH C-domain-like) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.
51868
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
The deposited structure of PDB entry 1f12 contains 2 copies of SCOP domain 51868 (6-phosphogluconate dehydrogenase-like, N-terminal domain) in Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. Showing 1 copy in chain A.

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