PDBe 1ey2

X-ray diffraction
2.3Å resolution

HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Homogentisate + O(2) = 4-maleylacetoacetate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homogentisate 1,2-dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 471 amino acids
Theoretical weight: 53.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93099 (Residues: 1-445; Coverage: 100%)
Gene names: HGD, HGO
Sequence domains: homogentisate 1,2-dioxygenase
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6322
Unit cell:
a: 157.809Å b: 157.809Å c: 95.147Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.193 0.242
Expression system: Escherichia coli