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EXTRACELLULAR DOMAIN OF THE 55KDA TUMOR NECROSIS FACTOR RECEPTOR. CRYSTALLIZED AT PH3.7 IN P 21 21 21.

X-ray diffraction
1.85Å resolution
PDB entry 1ext coloured by chain, front view.
PDB entry 1ext coloured by chain, side view.
PDB entry 1ext coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tumor necrosis factor-binding protein 1
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Multimeric state: homo dimer
Accessible surface area: 20175.94 Å2
Buried surface area: 3314.15 Å2
Dissociation area: 1,387.24 Å2
Dissociation energy (ΔGdiss): 10.02 kcal/mol
Dissociation entropy (TΔSdiss): 13.12 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-148577

Macromolecules

Tumor necrosis factor-binding protein 1
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19438 (Residues: 41-201; Coverage: 38%)
Gene names: TNFAR, TNFR1, TNFRSF1A
Pfam: TNFR/NGFR cysteine-rich region
InterPro:
CATH: Tumor Necrosis Factor Receptor, subunit A, domain 2
SCOP: TNF receptor-like
Tumor necrosis factor-binding protein 1 in PDB entry 1ext, assembly 1, front view.
Tumor necrosis factor-binding protein 1 in PDB entry 1ext, assembly 1, side view.
Tumor necrosis factor-binding protein 1 in PDB entry 1ext, assembly 1, top view.
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