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CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 1 COMPLEXED WITH GLUTAMATE

X-ray diffraction
2.2Å resolution
PDB entry 1ewk coloured by chain, front view.
PDB entry 1ewk coloured by chain, side view.
PDB entry 1ewk coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Metabotropic glutamate receptor 1
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Multimeric state: homo dimer
Accessible surface area: 37665.27 Å2
Buried surface area: 3726.61 Å2
Dissociation area: 951.81 Å2
Dissociation energy (ΔGdiss): -4.39 kcal/mol
Dissociation entropy (TΔSdiss): 14.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149948

Macromolecules

Metabotropic glutamate receptor 1
Chains: A, B
Length: 490 amino acids
Theoretical weight: 55.26 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23385 (Residues: 33-522; Coverage: 42%)
Gene names: Gprc1a, Grm1, Mglur1
Pfam: Receptor family ligand binding region
InterPro:
CATH: Rossmann fold
SCOP: L-arabinose binding protein-like
Metabotropic glutamate receptor 1 in PDB entry 1ewk, assembly 1, front view.
Metabotropic glutamate receptor 1 in PDB entry 1ewk, assembly 1, side view.
Metabotropic glutamate receptor 1 in PDB entry 1ewk, assembly 1, top view.
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