PDBe 1euu

X-ray diffraction
2.5Å resolution

SIALIDASE OR NEURAMINIDASE, LARGE 68KD FORM

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialidase Chain: A
Molecule details ›
Chain: A
Length: 605 amino acids
Theoretical weight: 64.65 KDa
Source organism: Micromonospora viridifaciens
UniProt:
  • Canonical: Q02834 (Residues: 43-647; Coverage: 99%)
Gene name: nedA
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 50.87Å b: 116.99Å c: 60Å
α: 90° β: 95.6° γ: 90°
R-values:
R R work R free
0.228 0.228 not available