PDBe 1es7

X-ray diffraction
2.9Å resolution

COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the BMP-2-BRIA ectodomain complex.
Nat. Struct. Biol. 7 492-6 (2000)
PMID: 10881198

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bone morphogenetic protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 116 amino acids
Theoretical weight: 13.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Bone morphogenetic protein receptor type-1A Chains: B, D
Molecule details ›
Chains: B, D
Length: 89 amino acids
Theoretical weight: 9.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36894 (Residues: 55-143; Coverage: 18%)
Gene names: ACVRLK3, ALK3, BMPR1A
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P65
Unit cell:
a: 109.33Å b: 109.33Å c: 101.905Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.19 0.229
Expression system: Escherichia coli