PDBe 1es0

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF THE MURINE CLASS II ALLELE I-A(G7) COMPLEXED WITH THE GLUTAMIC ACID DECARBOXYLASE (GAD65) PEPTIDE 207-220

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
H-2 class II histocompatibility antigen, A-D alpha chain Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.62 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P04228 (Residues: 24-205; Coverage: 78%)
Gene name: H2-Aa
Sequence domains:
Structure domains:
Glutamate decarboxylase 2 Chain: B
Molecule details ›
Chain: B
Length: 221 amino acids
Theoretical weight: 25.56 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q05329 (Residues: 207-236; Coverage: 4%)
Gene names: GAD2, GAD65
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2221
Unit cell:
a: 95.149Å b: 110.123Å c: 96.084Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.258
Expression system: Not provided