› 1ern

X-ray diffraction
2.4Å resolution

NATIVE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP]

Released:
DOI: 10.2210/pdb1ern/pdb
PDB entry 1ern coloured by chain, front view.
PDB entry 1ern coloured by chain, side view.
PDB entry 1ern coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation.
Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK, Wilson IA
Science 283 987-90 (1999)
PMID: 9974392

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148529 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythropoietin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19235 (Residues: 34-246; Coverage: 44%)
Gene name: EPOR
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P1
Unit cell:
a: 38.76Å b: 55.68Å c: 58.43Å
α: 62.65° β: 88.31° γ: 74.97°
R-values:
R R work R free
0.216 0.216 0.295
Expression system: Escherichia coli

Quick links

Citations

126 review citations

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Heinrich et al. (2003)
125 more

14 mentions without citation

50 Years of structural immunology.
Wilson et al. (2021)
13 more