PDBe 1ej6

X-ray diffraction
3.6Å resolution

Reovirus core

Released:
Source organism: Reovirus sp.
Primary publication:
Structure of the reovirus core at 3.6 A resolution.
Nature 404 960-7 (2000)
PMID: 10801118

Function and Biology Details

Reactions catalysed:
ATP + H(2)O = ADP + phosphate. 
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA. 
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero 300-mer (preferred)
hetero pentamer
hetero 25-mer
hetero 30-mer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Inner capsid protein sigma-2 Chains: D, E
Molecule details ›
Chains: D, E
Length: 418 amino acids
Theoretical weight: 47.16 KDa
Source organism: Reovirus sp.
UniProt:
  • Canonical: P11314 (Residues: 1-418; Coverage: 100%)
Gene name: S2
Sequence domains: Reoviral Sigma1/Sigma2 family
Inner capsid protein lambda-1 Chains: B, C
Molecule details ›
Chains: B, C
Length: 1275 amino acids
Theoretical weight: 142.01 KDa
Source organism: Reovirus sp.
UniProt:
  • Canonical: P15024 (Residues: 1-1275; Coverage: 100%)
Gene name: L3
Outer capsid protein lambda-2 Chain: A
Molecule details ›
Chain: A
Length: 1289 amino acids
Theoretical weight: 144.1 KDa
Source organism: Reovirus sp.
UniProt:
  • Canonical: P11079 (Residues: 1-1289; Coverage: 100%)
Gene name: L2
Sequence domains: Reovirus core-spike protein lambda-2 (L2)
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: F432
Unit cell:
a: 1,255Å b: 1,255Å c: 1,255Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.208