Structure analysis

HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN

X-ray diffraction
2.5Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 16300 Å2
Buried surface area: 3800 Å2
Dissociation area: 1,700 Å2
Dissociation energy (ΔGdiss): -8 kcal/mol
Dissociation entropy (TΔSdiss): 32 kcal/mol
Interface energy (ΔGint): -7 kcal/mol
Symmetry number: 2

Macromolecules

Chains: B, D
Length: 152 amino acids
Theoretical weight: 17.81 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P03406 (Residues: 54-205; Coverage: 74%)
Gene name: nef
InterPro:
CATH: Nef Regulatory Factor
SCOP: Regulatory factor Nef

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Chains: A, C
Length: 59 amino acids
Theoretical weight: 6.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 85-143; Coverage: 11%)
Gene name: FYN
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain

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