Function and Biology

CRYSTAL STRUCTURE OF METHYLMALONYL COA DECARBOXYLASE

Source organism: Escherichia coli
Biochemical function: lyase activity
Biological process: metabolic process
Cellular component: cytosol

EC 4.1.1.41: Methylmalonyl-CoA decarboxylase

Reaction catalysed:
(S)-methylmalonyl-CoA = propanoyl-CoA + CO(2).
Comments:
  • The enzyme from Veillonella alcalescens is a biotinyl-protein, requires sodium and acts as a sodium pump.
Systematic name:
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
Alternative Name(s):
  • (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase
  • Methylmalonyl-coenzyme A decarboxylase
  • Propionyl coenzyme A carboxylase
  • Propionyl-CoA carboxylase
  • (S)-methylmalonyl-CoA carboxy-lyase

Sequence family

CATH Protein family (Pfam)
PF00378
Domain description: Enoyl-CoA hydratase/isomerase
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
1 copy of Pfam domain PF00378 (Enoyl-CoA hydratase/isomerase) in Methylmalonyl-CoA decarboxylase in PDB 1ef8.

CATH InterPro annotations
IPR001753
Domain description: Crotonase superfamily
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
IPR018376
Domain description: Enoyl-CoA hydratase/isomerase, conserved site
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
IPR014748
Domain description: Crontonase, C-terminal
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
IPR029045
Domain description: ClpP/crotonase-like domain
Occurring in:
  1. Methylmalonyl-CoA decarboxylase

Structure domains

CATH CATH domains
3.90.226.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Homology: 2-enoyl-CoA Hydratase; Chain A, domain 1
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
1 copy of CATH domain 3.90.226.10 (2-enoyl-CoA Hydratase; Chain A, domain 1) in Methylmalonyl-CoA decarboxylase in PDB 1ef8.
1.10.12.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Lyase 2-enoyl-coa Hydratase; Chain A, domain 2
Homology: Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
1 copy of CATH domain 1.10.12.10 (Lyase 2-enoyl-coa Hydratase; Chain  A, domain 2) in Methylmalonyl-CoA decarboxylase in PDB 1ef8.
SCOP SCOP annotation
52103
Class: Alpha and beta proteins (a/b)
Fold: ClpP/crotonase
Superfamily: ClpP/crotonase
Occurring in:
  1. Methylmalonyl-CoA decarboxylase
1 copy of SCOP domain 52103 (Crotonase-like) in Methylmalonyl-CoA decarboxylase in PDB 1ef8.