PDBe 1ebv

X-ray diffraction
3.2Å resolution

Function and Biology Details

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chain: A
Molecule details ›
Chain: A
Length: 551 amino acids
Theoretical weight: 63.55 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P05979 (Residues: 33-583; Coverage: 96%)
Gene names: COX1, PTGS1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: I222
Unit cell:
a: 98.87Å b: 207.46Å c: 221.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.218 0.248