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Structure of the Rac/p67phox complex

Source organism: Homo sapiens
Biochemical function: Rho GDP-dissociation inhibitor binding
Biological process: regulation of neutrophil migration
Cellular component: ficolin-1-rich granule membrane

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF13181
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Neutrophil cytosol factor 2
The deposited structure of PDB entry 1e96 contains 1 copy of Pfam domain PF13181 (Tetratricopeptide repeat) in Neutrophil cytosol factor 2. Showing 1 copy in chain B.

PF00071
Domain description: Ras family
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 1e96 contains 1 copy of Pfam domain PF00071 (Ras family) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Neutrophil cytosol factor 2
IPR001806
Domain description: Small GTPase
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. Neutrophil cytosol factor 2
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR013105
Domain description: Tetratricopeptide repeat 2
Occurring in:
  1. Neutrophil cytosol factor 2
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR003578
Domain description: Small GTPase Rho
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1

Structure domains

CATH CATH domains
1.25.40.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Tetratricopeptide repeat domain
Occurring in:
  1. Neutrophil cytosol factor 2
The deposited structure of PDB entry 1e96 contains 1 copy of CATH domain 1.25.40.10 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Neutrophil cytosol factor 2. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 1e96 contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain A.
SCOP SCOP annotations
48453
Class: All alpha proteins
Fold: alpha-alpha superhelix
Superfamily: TPR-like
Occurring in:
  1. Neutrophil cytosol factor 2
The deposited structure of PDB entry 1e96 contains 1 copy of SCOP domain 48453 (Tetratricopeptide repeat (TPR)) in Neutrophil cytosol factor 2. Showing 1 copy in chain B.
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 1e96 contains 1 copy of SCOP domain 52592 (G proteins) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain A.

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