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Structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase

Source organism: Avian orthoavulavirus 1
Biochemical function: host cell surface receptor binding
Biological process: viral life cycle
Cellular component: viral envelope

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00423
Domain description: Haemagglutinin-neuraminidase
Occurring in:
  1. Hemagglutinin-neuraminidase
The deposited structure of PDB entry 1e8u contains 2 copies of Pfam domain PF00423 (Haemagglutinin-neuraminidase) in Hemagglutinin-neuraminidase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR016285
Domain description: Haemagglutinin-neuraminidase
Occurring in:
  1. Hemagglutinin-neuraminidase
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Hemagglutinin-neuraminidase
IPR000665
Domain description: Haemagglutinin/haemagglutinin-neuraminidase, paramyxovirus
Occurring in:
  1. Hemagglutinin-neuraminidase

Structure domain

CATH CATH domain
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Hemagglutinin-neuraminidase
The deposited structure of PDB entry 1e8u contains 2 copies of CATH domain 2.120.10.10 (Neuraminidase) in Hemagglutinin-neuraminidase. Showing 1 copy in chain B.
SCOP SCOP annotation
50940
Class: All beta proteins
Fold: 6-bladed beta-propeller
Superfamily: Sialidases
Occurring in:
  1. Hemagglutinin-neuraminidase
The deposited structure of PDB entry 1e8u contains 2 copies of SCOP domain 50940 (Sialidases (neuraminidases)) in Hemagglutinin-neuraminidase. Showing 1 copy in chain B.

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