› › Function and Biology

Structure of MurE the UDP-N-acetylmuramyl tripeptide synthetase from E. coli

Source organism: Escherichia coli
Biochemical function: acid-amino acid ligase activity
Biological process: cell wall organization
Cellular component: cytosol

Quick links

EC 6.3.2.13: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Reaction catalysed:
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
Systematic name:
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
Alternative Name(s):
  • MurE synthetase
  • UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming)
  • UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
  • UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase
  • UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
  • UDP-N-acetylmuramyl-tripeptide synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02875
Domain description: Mur ligase family, glutamate ligase domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of Pfam domain PF02875 (Mur ligase family, glutamate ligase domain) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.

PF08245
Domain description: Mur ligase middle domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of Pfam domain PF08245 (Mur ligase middle domain) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.

PF01225
Domain description: Mur ligase family, catalytic domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of Pfam domain PF01225 (Mur ligase family, catalytic domain) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036615
Domain description: Mur ligase, C-terminal domain superfamily
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
IPR036565
Domain description: Mur-like, catalytic domain superfamily
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
IPR005761
Domain description: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
IPR004101
Domain description: Mur ligase, C-terminal
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
IPR013221
Domain description: Mur ligase, central
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
IPR000713
Domain description: Mur ligase, N-terminal catalytic domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
IPR035911
Domain description: MurE/MurF, N-terminal
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Structure domains

CATH CATH domains
3.90.190.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Protein-Tyrosine Phosphatase; Chain A
Homology: Mur ligase, C-terminal domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of CATH domain 3.90.190.20 (Protein-Tyrosine Phosphatase; Chain A) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.
3.40.1190.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
Homology: Mur-like, catalytic domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of CATH domain 3.40.1190.10 (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.
3.40.1390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1
Homology: MurE/MurF, N-terminal domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of CATH domain 3.40.1390.10 (Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.
SCOP SCOP annotations
53245
Class: Alpha and beta proteins (a/b)
Fold: MurD-like peptide ligases, peptide-binding domain
Superfamily: MurD-like peptide ligases, peptide-binding domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of SCOP domain 53245 (MurCDEF C-terminal domain) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.
53624
Class: Alpha and beta proteins (a/b)
Fold: Ribokinase-like
Superfamily: MurD-like peptide ligases, catalytic domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of SCOP domain 53624 (MurCDEF) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.
63419
Class: Alpha and beta proteins (a/b)
Fold: MurF and HprK N-domain-like
Superfamily: MurE/MurF N-terminal domain
Occurring in:
  1. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
The deposited structure of PDB entry 1e8c contains 2 copies of SCOP domain 63419 (MurE/MurF N-terminal domain) in UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. Showing 1 copy in chain B.

Quick links