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GDP 4-keto-6-deoxy-D-mannose epimerase reductase S107A

Source organism: Escherichia coli
Biochemical function: NADP+ binding
Biological process: 'de novo' GDP-L-fucose biosynthetic process
Cellular component: cytoplasm

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EC 1.1.1.271: GDP-L-fucose synthase

Reaction catalysed:
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH
Systematic name:
GDP-beta-L-fucose:NADP(+) 4-oxidoreductase (3,5-epimerizing)
Alternative Name(s):
  • GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
  • GDP-L-fucose:NADP(+) 4-oxidoreductase (3,5-epimerizing)
  • GDP-fucose synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01370
Domain description: NAD dependent epimerase/dehydratase family
Occurring in:
  1. GDP-L-fucose synthase
The deposited structure of PDB entry 1e7q contains 1 copy of Pfam domain PF01370 (NAD dependent epimerase/dehydratase family) in GDP-L-fucose synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR028614
Domain description: GDP-L-fucose synthase/GDP-L-colitose synthase
Occurring in:
  1. GDP-L-fucose synthase
IPR001509
Domain description: NAD-dependent epimerase/dehydratase
Occurring in:
  1. GDP-L-fucose synthase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. GDP-L-fucose synthase

Structure domains

CATH CATH domains
3.90.25.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: UDP-galactose 4-epimerase; domain 1
Homology: UDP-galactose 4-epimerase, domain 1
Occurring in:
  1. GDP-L-fucose synthase
The deposited structure of PDB entry 1e7q contains 1 copy of CATH domain 3.90.25.10 (UDP-galactose 4-epimerase; domain 1) in GDP-L-fucose synthase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. GDP-L-fucose synthase
The deposited structure of PDB entry 1e7q contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in GDP-L-fucose synthase. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. GDP-L-fucose synthase
The deposited structure of PDB entry 1e7q contains 1 copy of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in GDP-L-fucose synthase. Showing 1 copy in chain A.

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