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CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX

X-ray diffraction
2.8Å resolution
PDB entry 1e0o coloured by chain, front view.
PDB entry 1e0o coloured by chain, side view.
PDB entry 1e0o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor 1 and Fibroblast growth factor receptor 2
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Multimeric state: hetero tetramer
Accessible surface area: 31205.97 Å2
Buried surface area: 10224.47 Å2
Dissociation area: 1,252.01 Å2
Dissociation energy (ΔGdiss): -16.21 kcal/mol
Dissociation entropy (TΔSdiss): 13.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138611

Macromolecules

Fibroblast growth factor 1
Chains: A, C
Length: 140 amino acids
Theoretical weight: 15.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Pfam: Fibroblast growth factor
InterPro:
CATH: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
SCOP: Fibroblast growth factors (FGF)
Fibroblast growth factor 1 in PDB entry 1e0o, assembly 1, front view.
Fibroblast growth factor 1 in PDB entry 1e0o, assembly 1, side view.
Fibroblast growth factor 1 in PDB entry 1e0o, assembly 1, top view.
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Fibroblast growth factor receptor 2
Chains: B, D
Length: 219 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21802 (Residues: 148-366; Coverage: 27%)
Gene names: BEK, FGFR2, KGFR, KSAM
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: I set domains
Fibroblast growth factor receptor 2 in PDB entry 1e0o, assembly 1, front view.
Fibroblast growth factor receptor 2 in PDB entry 1e0o, assembly 1, side view.
Fibroblast growth factor receptor 2 in PDB entry 1e0o, assembly 1, top view.
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