PDBe 1dtl

X-ray diffraction
2.15Å resolution

CRYSTAL STRUCTURE OF CALCIUM-SATURATED (3CA2+) CARDIAC TROPONIN C COMPLEXED WITH THE CALCIUM SENSITIZER BEPRIDIL AT 2.15 A RESOLUTION

Released:
Source organism: Gallus gallus
Primary publication:
Bepridil opens the regulatory N-terminal lobe of cardiac troponin C.
Proc. Natl. Acad. Sci. U.S.A. 97 5140-5 (2000)
PMID: 10792039

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.4 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09860 (Residues: 1-161; Coverage: 100%)
Gene name: TNNC1
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 36.27Å b: 62.04Å c: 62.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.276
Expression system: Escherichia coli