PDBe 1ds5

X-ray diffraction
3.16Å resolution

DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Casein kinase II subunit beta Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 23 amino acids
Theoretical weight: 2.77 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P67870 (Residues: 181-203; Coverage: 11%)
Gene names: CK2N, CSNK2B, G5A
Casein kinase II subunit alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 332 amino acids
Theoretical weight: 39.29 KDa
Source organism: Zea mays
Expression system: Escherichia coli
UniProt:
  • Canonical: P28523 (Residues: 1-332; Coverage: 100%)
Gene name: ACK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 87.681Å b: 119.846Å c: 145.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.289
Expression systems:
  • Not provided
  • Escherichia coli