Function and Biology

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+

EC 1.1.1.34: Hydroxymethylglutaryl-CoA reductase (NADPH)

Reaction catalysed:
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
Comments:
Systematic name:
(R)-mevalonate:NADP(+) oxidoreductase (CoA-acylating)
Alternative Name(s):
  • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
  • 3-hydroxy-3-methylglutaryl-CoA reductase
  • S-3-hydroxy-3-methylglutaryl-CoA reductase
  • Beta-hydroxy-beta-methylglutaryl coenzyme A reductase
  • HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
  • NADPH-hydroxymethylglutaryl-CoA reductase
  • Hydroxymethylglutaryl CoA reductase (NADPH)
  • Hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
  • HMG-CoA reductase
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  • Hydroxymethylglutaryl-CoA reductase (NADPH(2))

Sequence family

Pfam Protein family (Pfam)
PF00368
Domain description: Hydroxymethylglutaryl-coenzyme A reductase
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of Pfam domain PF00368 (Hydroxymethylglutaryl-coenzyme A reductase) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 1dqa.

InterPro InterPro annotations
IPR002202
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR023076
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR009029
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR009023
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR004554
Domain description: Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR023282
Domain description: Hydroxymethylglutaryl-CoA reductase, N-terminal
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR004816
Domain description: Hydroxymethylglutaryl-CoA reductase, metazoan
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR023074
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Structure domains

CATH CATH domains
3.90.770.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homology: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of CATH domain 3.90.770.10 (3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 1dqa.
3.30.70.420
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of CATH domain 3.30.70.420 (Alpha-Beta Plaits) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 1dqa.
1.10.3270.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: HMGR, N-terminal domain
Homology: HMGR, N-terminal domain
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of CATH domain 1.10.3270.10 (HMGR, N-terminal domain) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 1dqa.
SCOP SCOP annotations
56543
Class: Alpha and beta proteins (a+b)
Fold: Substrate-binding domain of HMG-CoA reductase
Superfamily: Substrate-binding domain of HMG-CoA reductase
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of SCOP domain 56543 (Substrate-binding domain of HMG-CoA reductase) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 1dqa.
55036
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: NAD-binding domain of HMG-CoA reductase
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of SCOP domain 55036 (NAD-binding domain of HMG-CoA reductase) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 1dqa.