PDBe 1dlh

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin HA1 chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/England/878/1969(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P04664 (Residues: 306-318; Coverage: 4%)
Gene name: HA
HLA class II histocompatibility antigen, DRB1-1 beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 188 amino acids
Theoretical weight: 21.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P04229 (Residues: 32-219; Coverage: 79%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 180 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P01903 (Residues: 28-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 94.6Å b: 94.6Å c: 247.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.304
Expression systems:
  • Not provided
  • Spodoptera