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THE CRYSTAL STRUCTURE OF E. COLI PSEUDOURIDINE SYNTHASE I AT 1.5 ANGSTROM RESOLUTION

Source organism: Escherichia coli
Biochemical function: catalytic activity, acting on RNA
Biological process: obsolete ncRNA processing
Cellular component: not assigned

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EC 5.4.99.12: tRNA pseudouridine(38-40) synthase

Reaction catalysed:
tRNA uridine(38-40) = tRNA pseudouridine(38-40)
Systematic name:
tRNA-uridine(38-40) uracil mutase
Alternative Name(s):
  • HisT
  • PSUI
  • TruA
  • tRNA pseudouridylate synthase I

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01416
Domain description: tRNA pseudouridine synthase
Occurring in:
  1. tRNA pseudouridine synthase A
The deposited structure of PDB entry 1dj0 contains 4 copies of Pfam domain PF01416 (tRNA pseudouridine synthase) in tRNA pseudouridine synthase A. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR001406
Domain description: Pseudouridine synthase I, TruA
Occurring in:
  1. tRNA pseudouridine synthase A
IPR020097
Domain description: Pseudouridine synthase I, TruA, alpha/beta domain
Occurring in:
  1. tRNA pseudouridine synthase A
IPR020095
Domain description: Pseudouridine synthase I, TruA, C-terminal
Occurring in:
  1. tRNA pseudouridine synthase A
IPR020103
Domain description: Pseudouridine synthase, catalytic domain superfamily
Occurring in:
  1. tRNA pseudouridine synthase A
IPR020094
Domain description: Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal
Occurring in:
  1. tRNA pseudouridine synthase A

Structure domains

CATH CATH domains
3.30.70.660
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Pseudouridine synthase I, catalytic domain, C-terminal subdomain
Occurring in:
  1. tRNA pseudouridine synthase A
The deposited structure of PDB entry 1dj0 contains 2 copies of CATH domain 3.30.70.660 (Alpha-Beta Plaits) in tRNA pseudouridine synthase A. Showing 1 copy in chain A.
3.30.70.580
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Pseudouridine synthase I, catalytic domain, N-terminal subdomain
Occurring in:
  1. tRNA pseudouridine synthase A
The deposited structure of PDB entry 1dj0 contains 2 copies of CATH domain 3.30.70.580 (Alpha-Beta Plaits) in tRNA pseudouridine synthase A. Showing 1 copy in chain A.
SCOP SCOP annotation
55121
Class: Alpha and beta proteins (a+b)
Fold: Pseudouridine synthase
Superfamily: Pseudouridine synthase
Occurring in:
  1. tRNA pseudouridine synthase A
The deposited structure of PDB entry 1dj0 contains 2 copies of SCOP domain 55121 (Pseudouridine synthase I TruA) in tRNA pseudouridine synthase A. Showing 1 copy in chain A.

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