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STRUCTURE OF 3,4-DICHLOROISOCOUMARIN-INHIBITED FACTOR D

Source organism: Homo sapiens
Biochemical function: hydrolase activity
Biological process: innate immune response
Cellular component: ficolin-1-rich granule lumen

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EC 3.4.21.46: Complement factor D

Reaction catalysed:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Alternative Name(s):
  • C3 convertase activator
  • C3 proactivator convertase
  • Factor D
  • Factor D (complement)
  • Properdin factor D esterase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Complement factor D
The deposited structure of PDB entry 1dic contains 1 copy of Pfam domain PF00089 (Trypsin) in Complement factor D. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Complement factor D
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Complement factor D
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Complement factor D
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Complement factor D
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Complement factor D
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Complement factor D

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Complement factor D
The deposited structure of PDB entry 1dic contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Complement factor D. Showing 2 copies in chain A.
SCOP SCOP annotation
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Complement factor D
The deposited structure of PDB entry 1dic contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Complement factor D. Showing 1 copy in chain A.

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